| Abstract
| - A short and efficient synthesis of l-2‘,3‘-dideoxy-2‘-trifluoromethyl-4‘-thiocytidines is described. (2R,4S/2S,4S)-5-(tert-Butyldimethylsiloxy)-2-trifluoromethylpentan-4-olide (3a and 3b) are prepared from α-trifluoromethyl-α,β-unsaturated ester (1) in three steps and converted tocompounds 6a and 6b. The corresponding 1-O-acetyl derivatives 8a and 8b were obtained via the usual Pummererrearrangement from 6a and 6b in two steps, which were inturn used to synthesize l-4‘-thiocytidines 10a and 10b.
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