| Abstract
| - The synthesis of macrocyclic tetraesters from 5-substituted isophthalic acids and 1,8-octane diolgave macrocylic metacyclophanes with the axially symmetric positions differentially protected.Dimer bis(metacyclophane)bolaamphiphiles proved to be extremely insoluble, but one derivativewas shown to have significant membrane activity. Very high continuous conductance and theformation of discrete single-ion channels were both observed, depending on how the compoundwas incorporated into the bilayer membrane.
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