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À propos de : Synthesis of Pyrroloquinolines as Indole Analogues of Flavonols        

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  • Synthesis of Pyrroloquinolines as Indole Analogues of Flavonols
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  • 7-Acetyl-4,6-dimethoxy-3-phenylindole 10 was converted into a range of 7-indolyl chalcones 13 byreaction with aryl aldehydes under basic conditions. Oxidation of the chalcones 13 with alkalinehydrogen peroxide gave the isolable epoxides 14, which were cyclized with further base treatmentinto the indole flavonols, or 5-hydroxy-6-oxopyrroloquinolines 15. The related compounds 25 and26, examples of indole flavanones and flavones, respectively, were also synthesized. UV spectroscopiccomparisons between flavonoids and indole flavonoids are discussed.
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