| Abstract
| - Reacting imine derivatives of resin-bound amino acids with α,ω-dihaloalkanes provides highlyversatile intermediates to racemic α,α-disubstituted amino acids with a wide variety of side-chainfunctionality. Two strategies were developed to convert the intermediate ω-chloro or ω-bromoderivatives to the desired products. Together, they allow the creation of amino acids with diversefunctionalities (ω-chlorides, nitriles, azides, acetates, thioacetates, thioethers, secondary and tertiaryaliphatic amines, and anilines) placed at varying chain lengths (2−5) from the α-center of the aminoacid.
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