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À propos de : Early Amidation Approach to3-[(4-Amido)pyrrol-2-yl]-2-indolinones        

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  • Early Amidation Approach to3-[(4-Amido)pyrrol-2-yl]-2-indolinones
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  • A new synthesis of 3-[(4-amido)pyrrol-2-yl]-2-indolinones has been developed, where the amide side chainwas installed prior to pyrrole formation. This strategyprecludes the need to use any coupling reagents to installthe amide side chain. This process includes a zinc-freealternative to the Knorr pyrrole synthesis.
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