Abstract
| - (4S,5S)-4-Formyl-5-vinyl-2-oxazolidinone (4b), which is readily obtained via a zinc−silver-mediatedreductive elimination of α-d-lyxofuranosyl phenyl sulfone (3b), is successfully converted to thenaturally occurring, nonproteinogenic amino acid (2S,3R)-3-amino-2-hydroxydecanoic acid (2). Alsoin this study, a facile “oxazolidinone rearrangement” reaction is uncovered during the attemptedformation of the (methylthio)thiocarbonate derivative of the oxazolidinone alcohol 7.
|