| Abstract
| - The methodology for the synthesis of podophyllotoxin and thuriferic acid-type lignans has beenapplied to derivatives carrying a naphthalene moiety. Starting from the 1,3-dithiane of 2-naphthaldehyde afforded the expected analogues in the 2,1-naphthalene series. The preferred conformations of these compounds are influenced by the bulky naphthalene system. By contrast, 1,8-bridgedproducts were obtained from the 1,3-dithiane of 1-naphthaldehyde. In this series, polycyclicnaphthalene lignan analogues were isolated after deprotection and/or desulfurization reactions.The cyclizations produced in this process are due to the proximity between the 3,4,5-trimethoxyphenyl moiety and the reacting C-2 of the 1,3-dithiane ring.
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