| Abstract
| - Enantiomerically pure (3‘R)- and (3‘S)-3‘,4‘-dihydrospiro[piperidine-2,3‘(2‘H)-benzopyran]s (R)-10and (S)-10 were successfully synthesized according to the CN(R,S) methodology with the aim ofserving as a pattern for the generation of related spirocyclic compounds. Two different syntheticpathways were studied starting from 2-cyano-6-phenyloxazolopiperidine (−)-2. One of them wasselected and used for the preparation of amines (R)-17 and (S)-17 starting from (−)-2 and (+)-2,respectively. The enantiomeric purity of all final aminochroman derivatives was determinated bycapillary electrophoresis using β-cyclodextrin as the chiral selector.
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