| Abstract
| - 5-Bromo-2-fluoro-3-pyridylboronic acid (3) wasprepared in high yield by ortho-lithiation of 5-bromo-2-fluoropyridine (1), followed by reaction with trimethylborate.Suzuki reaction of 3 with a range of aryl iodides gave3-monosubstituted 5-bromo-2-fluoropyridines 4 in excellentyields. A second Suzuki reaction utilizing the bromo constituent of 4 with aryl and heteroaryl boronic acids provided3,5-disubstituted 2-fluoropyridines 5, which in turn couldbe converted to the corresponding 2-pyridones 6.
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