Abstract
| - The C2-symmetric macrodiolide core 2 of an antiviral agent, macroviracin A (1), was constructedin a single step by the intermolecular macrodimerization of C22-hydroxy carboxylic acid 3 with2-chloro-1,3-dimethylimidazolinium chloride and DMAP in the presence of sodium hydride (NaH).The use of potassium hydride instead of NaH caused the intramolecular cyclization, predominantlyproviding the corresponding monomer 26. The acid 3 was synthesized through a series of reactionssuch as the coupling reaction of acetylene 5 and oxirane 6, stereoselective glycosidation with thetrichloroacetimidate method, and Jones oxidation.
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