Indirect Trapping of the RetroconjugateAddition Reaction Intermediate Involvedin the Epimerization of Lobeline: Application to the Synthesis of(−)-Sedamine
Alkyl chloroformates induced indirect trappingof the retroconjugate addition reaction intermediate involvedin the epimerization of lobeline is described. This strategywas applied to the conversion of (−)-lobeline to (−)-sedaminein high overall yield.