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À propos de : A Concise Synthesis of a Novel Antiangiogenic Tyrosine KinaseInhibitor        

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  • A Concise Synthesis of a Novel Antiangiogenic Tyrosine KinaseInhibitor
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  • An efficient synthesis of the potent KDR inhibitor 3-[5-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-1H-indole-2-yl]quinolin-2(1H)-one (1) is described. The process features a noncryogenic indoleboronation and a dicyclohexylamine-mediated Suzuki coupling.
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