| Abstract
| - In this paper, we describe a thermal [2 + 2] cycloadditioninvolving 2-acylaminoacrylates as electron-poor acceptoralkenes, a reaction that involves a Michael−Dieckmann-typeprocess. The reaction gives rise to a new substituted cyclobutane skeleton that can be transformed into amino acidderivatives. For example, a number of transformations werecarried out to give the two pairs of stereoisomers of the2-hydroxycyclobutane-α-amino acid serine analogue (c4Ser);compounds 22 and 23. This synthesis covers a gap inknowledge in the broad field of restricted amino acids.
|
