| Abstract
| - An efficient synthesis of substituted azolopyrimidines suchas pyrido[3‘,2‘:4,5]pyrrolo[1,2-c]pyrimidines, pyrimido[1,6-a]indoles, benzo[4,5]imidazo-[1,2-c]pyrimidines, an imidazo[1,2-c]pyrimidine, and pyrazolo[1,5-c]pyrimidines is described. The method involves the reaction of N-protectedbromomethylazoles and tosylmethyl isocyanide (TosMIC)derivatives in nonanhydrous media. The study of the reaction conditions shows that the method is only successfulunder phase-transfer conditions (CH2Cl2/30% aq NaOH)using benzyltriethylammonium chloride as a catalyst.
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