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À propos de : Novel and Efficient Access to Phenylamino-pyrimidine TypeProtein Kinase C Inhibitors Utilizing a Negishi Cross-CouplingStrategy        

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  • Novel and Efficient Access to Phenylamino-pyrimidine TypeProtein Kinase C Inhibitors Utilizing a Negishi Cross-CouplingStrategy
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  • A novel, short, and efficient synthetic pathway to 3-{4-[2-(3-chlorophenylamino)-pyrimidin-4-yl]-pyridin-2-ylamino}-propanol (CGP 60474) and a series of analogues was developed. The syntheticsequence consisted of a Negishi-type cross-coupling reaction in the key step followed by twosubsequent nucleophilic substitution reactions. This strategy represents a versatile and robustprotocol to access diverse analogues of the title compound for subsequent SAR studies as potentialphenylamino-pyrimidine type protein kinase C inhibitors.
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