Documentation scienceplus.abes.fr version Bêta

À propos de : Opening of Aryl-Substituted Epoxides To Form QuaternaryStereogenic Centers: Synthesis of (−)-Mesembrine        

AttributsValeurs
type
Is Part Of
Subject
Title
  • Opening of Aryl-Substituted Epoxides To Form QuaternaryStereogenic Centers: Synthesis of (−)-Mesembrine
has manifestation of work
related by
Author
Abstract
  • Cycloalkanones are easily converted into aryl-substituted cyclic alkenes by the addition of an arylGrignard reagent followed by dehydration. These alkenes are good substrates for asymmetricepoxidation. We have found that the addition of allylic and benzylic Grignard reagents can occurpreferentially at the benzylic position of the derived epoxides to give the quaternary stereogeniccenter. This approach led to a short synthesis of the nanomolar serotonin re-uptake inhibitor (−)-mesembrine.
article type
is part of this journal



Alternative Linked Data Documents: ODE     Content Formats:       RDF       ODATA       Microdata