| Abstract
| - We report herein a practical synthesis of 4‘-thiothymidine(15) and appropriately protected 2‘-deoxy-4‘-thiocytidine(16), -thioadenosine (27), and -thioguanosine (29) derivatives, substrates for the synthesis of 4‘-thioDNA, from thecorresponding 4‘-thioribonucleosides. 2‘-Deoxy-4‘-thiopyrimidine nucleosides were synthesized using a radical reactionof the corresponding 2‘-α-bromo derivatives, which wereprepared via 2,2‘-O-anhydro derivatives. 2‘-Deoxy-4‘-thiopurine nucleosides were synthesized using the same radicalreaction of the corresponding 2‘-β-bromo derivatives.
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