About: Synthesis of Somatostatin Mimetics Based on the1-Deoxymannojirimycin Scaffold

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Attributs	Valeurs
type	work Article
Is Part Of	http://hub.abes.fr/acs/periodical/joceah/2005/volume_70/issue_21/w
Subject	Article
Title	Synthesis of Somatostatin Mimetics Based on the1-Deoxymannojirimycin Scaffold
has manifestation of work	http://hub.abes.fr/acs/periodical/joceah/2005/volume_70/issue_21/101021jo051454n/m/print http://hub.abes.fr/acs/periodical/joceah/2005/volume_70/issue_21/101021jo051454n/m/web
related by	http://hub.abes.fr/acs/periodical/joceah/2005/volume_70/issue_21/101021jo051454n/authorship/1 http://hub.abes.fr/acs/periodical/joceah/2005/volume_70/issue_21/101021jo051454n/authorship/2
Author	Murphy Paul V. Gouin Sebastien G.
Abstract	A novel synthesis of somatostatin mimetics based on the 1-deoxymannojirimycin (DMJ) scaffoldhas been developed. This involved development of a route suitable for the strategic grafting ofpharmacophoric tryptophan and lysine side chains to the nitrogen atom of the piperidine ring andto the primary hydroxyl group of DMJ, respectively. The novel peptidomimetics were found to bindwith higher affinity to sst4 receptors than to sst5 receptors.
article type	research-article
is part of this journal	The Journal of Organic Chemistry

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