| Abstract
| - A novel “protecting group-dependent” alkylation strategy was developed for complementarydiastereoselective syntheses of α,α‘-syn- and α,α‘-anti-bis-alkenes 2 and 3, which represent ring-closing metathesis (RCM) substrates for medium-sized oxacycles. This principle has been appliedto a stereoselective and concise total synthesis of (−)-isoprelaurefucin (4) in 14 steps in 12% overallyield from known epoxide 8.
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