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À propos de : Chirality Transfer from Guanidinium Ylides to 3-Alkenyl(or 3-Alkynyl) Aziridine-2-carboxylates and Application to theSyntheses of (2R,3S)-3-Hydroxyleucinate andd-erythro-Sphingosine        

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  • Chirality Transfer from Guanidinium Ylides to 3-Alkenyl(or 3-Alkynyl) Aziridine-2-carboxylates and Application to theSyntheses of (2R,3S)-3-Hydroxyleucinate andd-erythro-Sphingosine
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  • Reaction of chiral guanidinium ylides with α,β-unsaturated aldehydes gives 3-(α,β-unsaturated)aziridine-2-carboxylates in high diastereo- and enantioselectivities (up to 93% diastereomeric excessand 98% enantiomeric excess). 3-(1-Methylvinyl)- and 3-[(E)-pentadec-1-enyl]aziridine-2-carboxylateswere successfully employed to prepare (2R,3S)-3-hydroxyleucinate and d-erythro-sphingosine,respectively.
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