| Abstract
| - A facile and efficient synthetic route toward highly substituted 2,3-dihydrothiopyran-4-ones 2 has been developed viaa formal [5C + 1S] annulation of readily available α-alkenoylketene-(S,S)-acetals 1 with sodium sulfide nonahydrated salt(Na2S·9H2O) and utilized in the synthesis of 2-(4-chlorophenyl)-6-(morpholin-4-yl)-4H-thiopyran-4-one 5l, an inhibitor ofDNA-dependent protein kinase (DNA-PK).
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