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| Title
| - Improving Glycopeptide Synthesis: A Convenient Protocol for thePreparation of β-Glycosylamines and the Synthesis ofGlycopeptides
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| - Herein we apply a recently introduced protocol using ammonium carbamate in methanol to theamination of crude chitobiose leading to 1,β-aminochitobiose. This simple, one-step procedure allowsa facile preparation of unstable glycosylamines in contrast to the commonly implemented ammoniumbicarbonate based amination of water-soluble carbohydrates. The new amination protocol leads toan improved synthesis of the key chitobiosyl-asparagine building block for the SPPS of glycopeptides.The utility of the method is demonstrated with the synthesis of a 39-amino acid glycoprotein.
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