| Abstract
| - A Claisen rearrangement/iodolactamization sequence starting from commercially available trifluoroacetaldehyde methyl hemiacetal, followed by a classical chemical resolution, provided enantiomerically pure4,4-difluoro-3,3-dimethylproline (S)-1. No hazardous fluorination reagents were used, and the overallyield over 12 steps was greater than 28%.
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