About: Synthesis of Functionalized Pyrrolidin-2-ones and(S)-Vigabatrin from Pyrrole

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Attributs	Valeurs
type	work Article
Is Part Of	http://hub.abes.fr/acs/periodical/joceah/2006/volume_71/issue_5/w
Subject	Note
Title	Synthesis of Functionalized Pyrrolidin-2-ones and(S)-Vigabatrin from Pyrrole
has manifestation of work	http://hub.abes.fr/acs/periodical/joceah/2006/volume_71/issue_5/101021jo0524472/m/web http://hub.abes.fr/acs/periodical/joceah/2006/volume_71/issue_5/101021jo0524472/m/print
related by	http://hub.abes.fr/acs/periodical/joceah/2006/volume_71/issue_5/101021jo0524472/authorship/1 http://hub.abes.fr/acs/periodical/joceah/2006/volume_71/issue_5/101021jo0524472/authorship/2 http://hub.abes.fr/acs/periodical/joceah/2006/volume_71/issue_5/101021jo0524472/authorship/3
Author	Reiser Oliver Gheorghe Alexandru Schulte Michael
Abstract	Starting from pyrrole, the novel 3,4-didehydropyrohomoglutamate 8 or (ent)-8 can be efficiently synthesized in upto 91% ee, which can be utilized as a versatile building blocktoward functionalized pyrrolidin-2-ones. Moreover, (ent)-8can be readily converted to (S)-Vigabatrin, being an irreversible inhibitor for GABA-T, which is used as adjunctivetherapy in patients that suffer from epilepsy.
article type	brief-report
is part of this journal	The Journal of Organic Chemistry

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