| Abstract
| - From a structure−activity relationship perspective, the newabietane 5 having cyano groups at C-2 and C-13 and aphenolic ring C has been synthesized and evaluated biologically because the related compound 4 has high potency ininflammation models in vitro and in vivo. Compound 5 wassynthesized from 8, which was obtained in five steps fromthe known compound 9, via an unexpected aromatizationcaused by the addition of PhSeCl and subsequent oxidation/elimination of the selenated intermediate 14 with H2O2.
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