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À propos de : Highly Diastereoselective Synthesis ofβ-Carboxy-γ-lactams and Their Ethyl Esters viaSc(OTf)3-Catalyzed Imino Mukaiyama-AldolType Reaction of 2,5-Bis(trimethylsilyloxy)furanwith Imines        

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  • Highly Diastereoselective Synthesis ofβ-Carboxy-γ-lactams and Their Ethyl Esters viaSc(OTf)3-Catalyzed Imino Mukaiyama-AldolType Reaction of 2,5-Bis(trimethylsilyloxy)furanwith Imines
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  • Functionalized γ-lactams are found to be crucial intermediates in the synthesis of biologically important naturalproducts. We herein described a highly diastereoselectivesynthesis of β-carboxy-γ-lactams and their ethyl esterderivatives, in high yields with high diastereomeric ratio,via the Mukaiyama-aldol type reaction of 2,5-bis(trimethysilyloxy)furan with imines, employing Sc(OTf)3 as a catalyst.
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