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À propos de : Expedient Syntheses of Antofine and Cryptopleurine viaIntramolecular 1,3-Dipolar Cycloaddition        

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  • Expedient Syntheses of Antofine and Cryptopleurine viaIntramolecular 1,3-Dipolar Cycloaddition
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  • The practical and expedient total syntheses of the representative phenanthroindolizidine and phenanthroquinolizidine alkaloids, antofine and cryptopleurine, are described. Construction of the pyrrolidineand piperidine ring of each alkaloid was achieved by using an intramolecular 1,3-dipolar cycloadditionof an azide onto an alkene and subsequent reduction of the resulting imine and aziridine.
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