| Abstract
| - Aziridines were formed by copper-catalyzed intramolecular nitrene addition to alkenes. The carbamategroup was used as the tether between the alkene and the nitrene. Subsequent nucleophilic attack of theaziridine was accomplished using RSH, R2NH, N3-, or ROH as the nucleophile. This addition was foundto be regio- and stereoselective. This methodology has been used to demonstrate its utility in the regio-and stereoselective synthesis of a 1,2-diamino-3-hydroxycyclohexane. This substitution pattern is foundin natural products such as Tamiflu.
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