Abstract
| - The synthesis of N-substituted 5-nitroanthranilic acid derivatives 3a-w was achieved by a new, mild, microwave-assisted,regioselective amination reaction of 5-nitro-2-chlorobenzoicacid (1a) with a diverse range of aliphatic and aromaticamines 2a-w without added solvent or catalyst. Up to >99%isolated yield was obtained within 5−30 min at 80−120 °C.The reaction, which is suitable for upscaling, yielded newcompounds that are of considerable interest as useful buildingblocks and as potential drugs.
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