| Abstract
| - In this note, we describe the design, synthesis, and structuralstudies of novel hybrid foldamers derived from Aib-Pro-Adb building blocks that display repeat β-turn structuremotif. The foldamer having a conformationally constrainedaliphatic−aromatic amino acid conjugate adopts a well-defined, compact, three-dimensional structure, governed bya combined conformational restriction imposed by theindividual amino acids with which it is made of. Conformational investigations by single-crystal X-ray and solution-state NMR studies were undertaken to investigate theconformational preference of these foldamers with a hetero-backbone. Our findings suggest that constrained aliphatic−aromatic amino acid conjugates would offer new avenuesfor the de novo design of hybrid foldamers with distinctivestructural architectures.
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