| Attributs | Valeurs |
|---|
| type
| |
| Is Part Of
| |
| Subject
| |
| Title
| - Alkenenitriles: Conjugate Additions of Alkyl Iodides with aSilica-Supported Zinc−Copper Matrix in Water
|
| has manifestation of work
| |
| related by
| |
| Author
| |
| Abstract
| - A new silica-supported zinc-copper matrix reagent promotes the conjugate addition of alkyl iodides tocyclic and acyclic alkenenitriles in water. X-ray diffraction and electron microscopy techniques suggestthat the active copper species generated from elemental zinc and copper(I) iodide is finely dispersed,zerovalent copper. Alkyl iodides react with the silica-supported reagent to generate putative radicaloidintermediates that efficiently add to alkenenitriles to provide β-substituted nitriles. Conjugate additionsto acyclic and cyclic 5−7-membered alkenenitriles are most effective for primary alkyliodides, althoughsecondary and tertiary alkyliodides are viable reaction partners. The strategy addresses the challenge ofperforming conjugate additions to disubstituted alkenenitriles and demonstrates the beneficial role of thesilica-supported reagent.
|
| article type
| |
| is part of this journal
| |
