| Abstract
| - Recent support studies on the total synthesis of the welwistatin system are described. The target stepinvolves lead-mediated arylation of sterically demanding aryl groups and carbon acid coupling partnersin order to establish the highly congested tetracyclic core structure. Type 7 β-ketoesters and β-ketonitrileswere successfully arylated with a variety of ortho- and meta-substituted aryllead compounds generatedby a halogen−boron−lead exchange sequence. The enolates of compounds 15, 19, and 25, each bearingall-carbon quaternary centers adjacent to the arylation site, failed to couple.
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