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À propos de : Intriguing Behavior of Cinchona Alkaloids in theEnantioselective OrganocatalyticHydroxyamination ofα-Substituted-α-cyanoacetates        

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  • Intriguing Behavior of Cinchona Alkaloids in theEnantioselective OrganocatalyticHydroxyamination ofα-Substituted-α-cyanoacetates
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  • The cinchona alkaloid quinine promotes the enantioselectivenitroso-aldol reaction between α-aryl-α-cyanoacetates andnitrosobenzene to give the hydroxyamination products withtotal chemoselectivity. Treatment of the reaction mixture withZn/AcOH affords the corresponding amines in high yieldand moderate enantioselectivity. An unusual effect on theenantioselectivity was observed with the catalyst loading andsolvent. A reductive protocol allows the construction of anoptically active 1,2-diamine moiety bearing a quaternarycenter.
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