Abstract
| - An efficient, high-yielding Lewis acid promoted deprotectionof O-trityl hydroxylamine derivatives is described. A rangeof acid-labile protecting groups, such as N-Boc and O-TBS,were tolerated under these mild conditions. The presentmethod is applicable to the synthesis of a broad range ofhydroxylamine derivatives, including N-hydroxy amides(hydroxamic acids), N-hydroxy sulfonamides, and N-hydroxyureas, which often exhibit significant biological activities.An application of this methodology for a concise synthesisof (−)-Cobactin T (18) is also demonstrated.
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