Documentation scienceplus.abes.fr version Bêta

À propos de : Mild and Efficient Lewis Acid-PromotedDetritylation in the Synthesis of N-HydroxyAmides: A Concise Synthesis of (−)-Cobactin T        

AttributsValeurs
type
Is Part Of
Subject
Title
  • Mild and Efficient Lewis Acid-PromotedDetritylation in the Synthesis of N-HydroxyAmides: A Concise Synthesis of (−)-Cobactin T
has manifestation of work
related by
Author
Abstract
  • An efficient, high-yielding Lewis acid promoted deprotectionof O-trityl hydroxylamine derivatives is described. A rangeof acid-labile protecting groups, such as N-Boc and O-TBS,were tolerated under these mild conditions. The presentmethod is applicable to the synthesis of a broad range ofhydroxylamine derivatives, including N-hydroxy amides(hydroxamic acids), N-hydroxy sulfonamides, and N-hydroxyureas, which often exhibit significant biological activities.An application of this methodology for a concise synthesisof (−)-Cobactin T (18) is also demonstrated.
article type
is part of this journal



Alternative Linked Data Documents: ODE     Content Formats:       RDF       ODATA       Microdata