Documentation scienceplus.abes.fr version Bêta

À propos de : Synthesis of Branched Oligonucleotides with Three DifferentSequences Using an Oxidatively Removable Tritylthio Group        

AttributsValeurs
type
Is Part Of
Subject
Title
  • Synthesis of Branched Oligonucleotides with Three DifferentSequences Using an Oxidatively Removable Tritylthio Group
has manifestation of work
related by
Author
Abstract
  • We synthesized a three-way branched oligodeoxynucleotide (ODN) 30-mer using a new branch unitwith acid-labile DMTr and oxidatively cleavable TrS groups as orthogonal protecting groups. The branchedODN was successfully synthesized using 5-[3,5-bis(trifluoromethyl)phenyl]-1H-tetrazole and (2R,8aS)-(+)-(camphorylsulfonyl)oxaziridine as the activator of phosphoramidite units and the oxidizing reagent,respectively. We also found that the TrS group was orthogonal to the Lev, TBDMS, and Fmoc groups.These results indicate the possibility of the synthesis of more complex four- and five-way branchedODNs by the combined use of DMTr, TrS, Lev, TBDMS, and Fmoc groups.
article type
is part of this journal



Alternative Linked Data Documents: ODE     Content Formats:       RDF       ODATA       Microdata