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À propos de : Total Synthesis of Streptonigrone        

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  • Total Synthesis of Streptonigrone
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  • A total synthesis of streptonigrone, 1, is described, which incorporates a one-step synthesis of substitutedpyridones devised in our laboratory. Other aspects of the synthesis that differentiate the present approachfrom previous ones are the use of a Conrad−Limpach reaction, rather than the customary Friedländermethodology, to assemble the quinoline segment of 1, and the implementation of an anionic sequencefor the functionalization of a key pyridone intermediate.
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