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À propos de : A Practical Synthesis of Differentially Protected2-(Hydroxymethyl)piperazines        

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  • A Practical Synthesis of Differentially Protected2-(Hydroxymethyl)piperazines
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  • An efficient and scalable synthesis of three differentiallyprotected 2-(hydroxymethyl)piperazines is presented, startingfrom optically active and commercially available (2S)-piperazine-2-carboxylic acid dihydrochloride. These syntheticbuilding blocks are useful in the preparation of biologicallyactive compounds and as chemical scaffolds for the construction of combinatorial libraries.
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