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À propos de : TFA-Mediated Tandem Friedel−CraftsAlkylation/Cyclization/Hydrogen TransferProcess for the Synthesis of FlavyliumCompounds        

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  • TFA-Mediated Tandem Friedel−CraftsAlkylation/Cyclization/Hydrogen TransferProcess for the Synthesis of FlavyliumCompounds
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  • The tandem reaction of phenols and chalcones in refluxingTFA gave the flavylium species of 2-hydroxy-2-phenyl-2H-chromenes in moderate to good isolated yields. The reactionwas proposed to involve a tandem transformation of Friedel−Crafts alkylation, dehydrative cyclization, intermolecularhydrogen transfer, and hydration. As a multifunctionalcatalyst, TFA mediated the processes efficiently and cleanly.
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