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À propos de : Diastereoselective Synthesis of Glutamate-Appended Oxolane Rings: Synthesis of (S)-(+)-Lycoperdic Acid        

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  • Diastereoselective Synthesis of Glutamate-Appended Oxolane Rings: Synthesis of (S)-(+)-Lycoperdic Acid
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  • The stereocontrolled synthesis of the glutamate-containing natural product (S)-(+)-lycoperdic acid isdescribed. The key transformation in the synthetic route was an efficient diastereoselective annulation ofan oxolane ring onto a pyroglutamate scaffold to construct either a γ,γ-disubstituted glutamate-appendedtetrahydrofuran or a γ-lactone. The reaction sequence also featured an improved method for thehalogenation of pyroglutamate derivatives in high yield with enhanced stereoselection.
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