| Abstract
| - New pyrroloisoquinoline-based tetrapeptides were synthesized in enantiomerically pure form, and their conformationalfeatures were studied by NMR, IR, and molecular-modelingtechniques. The presence of a reverse turn was observed inboth structures, with the C1 stereochemistry playing a centralrole in determining stable conformations. In particular, allof the analyses led to the conclusion that a type II‘ β-turn ismostly stabilized in tetrapeptide mimic 3a, while a typicalinverse γ-turn geometry is revealed for the diastereoisomer3b.
|
