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À propos de : Synthesis of Tricyclic Heterocycles via a Tandem ArylAlkylation/Heck Coupling Sequence        

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  • Synthesis of Tricyclic Heterocycles via a Tandem ArylAlkylation/Heck Coupling Sequence
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  • A norbornene-mediated palladium-catalyzed sequence is described in which two alkyl−aryl bonds andone alkenyl−aryl bond are formed in one pot with use of microwave irradiation. A variety of symmetricaland unsymmetrical oxygen-, nitrogen-, silicon-, and sulfur-containing tricyclic heterocycles weresynthesized from a Heck acceptor and an aryl iodide containing two tethered alkyl halides. This approachwas further applied to the synthesis of a tricyclic mescaline analogue.
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