Abstract
| - Acyclic receptors incorporating neutral and cationic recognition sites show effective binding ofN-acetylneuraminic acid (Neu5Ac), the most naturally abundant sialic acid, in highly competitive solventssuch as dimethyl sulfoxide (DMSO) and water/DMSO. Receptors 6b and 7b are able to form neutral/charge-reinforced hydrogen bonds and ion pairs with Neu5Ac, similar to sialic acid-binding proteins.Syntheses and binding properties of the artificial receptors are discussed.
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