Abstract
| - An efficient, stereospecific synthesis of the alkaloids senepodine G (2) and cermizine C (1) has been completed usingthe BF3·Et2O-promoted stereospecific addition of Me2CuLito α,β-unsaturated lactam 6 to provide lactam 3, the additionof MeMgBr followed by HCl to convert 3 to senepodine G(2) (six steps, 40% overall yield), and the stereospecificNaBH4 reduction of 2 to give cermizine C (1) (seven steps,40% overall yield).
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