| Abstract
| - Quaternary stereocenters on a 2-cyclohexen-1-one ring are synthesized with good to excellent levels ofenantioselectivity. The quaternary stereocenter is created through a new synthetic sequence involvingthree reactions: the enantioselective Birch reduction-allylation, enol ether hydrolysis, and the Coperearrangement. To illustrate the ability of the sequence to enantioselectively generate complex structures,a variety of substrates are described. Notably, the sequence works for the enantioselective generation ofvicinal quaternary-tertiary stereocenters, the generation of congested arylic quaternary stereocenters, andhydroxyalkyl substituted quaternary stereocenters.
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