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À propos de : Intramolecular PIFA-Mediated AlkyneAmidation and Carboxylation Reaction        

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  • Intramolecular PIFA-Mediated AlkyneAmidation and Carboxylation Reaction
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  • The hypervalent iodine reagent PIFA promotes the intramolecular electrophilic cyclization of easily accessible alkynylamides and alkynyl carboxylic acids, leading to the formationof pyrrolidinone and lactone skeletons, respectively, in a veryefficient way. A synthetic study and a mechanistic proposalfor these transformations are presented.
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