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À propos de : An Improved Understanding of the Reaction ofBis(bromomethyl)quinoxaline 1-N-Oxides with Amines UsingSubstituent Effects        

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  • An Improved Understanding of the Reaction ofBis(bromomethyl)quinoxaline 1-N-Oxides with Amines UsingSubstituent Effects
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  • The reaction of bis(bromomethyl)quinoxaline N-oxides with amines is interesting from a reactionmechanism perspective and due to the reported biological activity of compounds in this general class.The complex mechanism of this reaction (particularly in the case of primary amines) is complicatedfurther when C6 or C7 substituted mono-N-oxides are considered. In this study, the synthesis andsubsequent characterization of a series of 2,3-bis(bromomethyl)quinoxaline 1-N-oxides is reported.Experimental and computational evidence is used to show that the observed product ratios from thereaction with diethylamine reflect the influence of both the C6/C7 substituent and the N-oxide functionalgroup on the initial nucleophilic substitution reaction.
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