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À propos de : Synthesis of Neoglycoconjugates by the Desulfurative Rearrangement of Allylic Disulfides        

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  • Synthesis of Neoglycoconjugates by the Desulfurative Rearrangement of Allylic Disulfides
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Abstract
  • Two series of neoglycosyl donors are prepared on the basis of connection of an allylic disulfide motif to the anomeric center via a simple O-glycosyl linkage or N-glycosyl amide unit. Conjugation of both sets of donors to cysteine in peptides is demonstrated through classical disulfide exchange followed by the phosphine-mediated desulfurative allylic rearrangement resulting in neoglycopeptides characterized by a simple thioether spacer. The conjugation reaction functions in the absence of protecting groups on both the neoglycosyl donor and peptide in aqueous media at room temperature.
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  • Synthesis of Neoglycoconjugates
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