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À propos de : N-Isopropylsulfinylimines as Useful Intermediatesin the Synthesis of Chiral Amines: ExpeditiveAsymmetric Synthesis of the Calcimimetic(+)-NPS R-568        

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  • N-Isopropylsulfinylimines as Useful Intermediatesin the Synthesis of Chiral Amines: ExpeditiveAsymmetric Synthesis of the Calcimimetic(+)-NPS R-568
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  • An efficient and high-yielding approach for the asymmetricsynthesis of calcimimetic (+)-NPS R-568 (1) has beendeveloped. The key step of the synthesis is the highlydiastereoselective addition of methyl Grignard to the (SS,E)-N-(3-methoxybenzylidene)-2-propanesulfinamide [5(S)], whichafforded a single diastereoisomer in high yield in shortreaction time
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