| Abstract
| - Synthesis of the tricyclic core of madangamine alkaloids hasbeen achieved in a 10-step sequence starting from a 4-(aminomethyl)anisole derivative. A Birch reduction and acylationwith cyanoacetic acid followed by an intramolecular Michaelprocess renders a polyfunctionalized cis-perhydroisoquinoline. A diastereoselective allylation and reduction of amide,nitrile, and ketone groups leads to a bicyclic alcohol, whichundergoes aminocyclization through the nosyl derivative tothe diazatricyclic ring.
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