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À propos de : Synthesis of Enantiopure 1-Arylprop-2-en-1-ols and Their tert-Butyl Carbonates        

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  • Synthesis of Enantiopure 1-Arylprop-2-en-1-ols and Their tert-Butyl Carbonates
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  • Enantiomerically pure 1-arylpropenols 8 have been prepared by resolution of the corresponding racemates, using the lipase formulation Novozyme 435. Deprotonation of the latter alcohols with n-BuLi, followed by derivatization with (t-BuO)2CO, afforded the corresponding carbonates 5. Optimization of the process is presented.
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